According to the prescribing information for zetia, its effect for the prevention of heart attacks has not been determined.

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ZETIAadministered in combination with fenofibrateis indicated as adjunctive therapy to diet for the reduction of elevated total-CLDL-CApo Band non-HDL-C in adult patients with mixed hyperlipidemia.

No dosage adjustment is necessary in patients with renal impairmentsee CLINICAL PHARMACOLOGYWhen given with simvastatin in patients with moderate to severe renal impairmentestimated glomerular filtration rate.

EzetimibeZetiais distinct from these agents because it does not inhibit cholesterol synthesis in the liver or increase bile acid excretionIt belongs to a class of lipid-lowering compounds that selectively inhibits the intestinal absorption of cholesterol and related phytosterolsEzetimibe’s pharmacological effect is complementary to that of the statins1

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