Promethazine and codeine may cause marked drowsiness or may impair the mental and or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery.
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Promethazine hydrochloride tablets are contraindicated in comatose statesand in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazinesAntihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms including asthma.
Long-term animal studies have not been performed to assess the carcinogenic potential of promethazinenor are there other animal or human data concerning carcinogenicitymutagenicity or impairment of fertility with this drugPromethazine was nonmutagenic in the Salmonella test system of Ames.
Use of promethazine hydrochloride tablets in patients with compromised respiratory functione.gCOPDsleep apneashould be avoided.
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