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Anal prurituspseudomembranous colitisClostridium difficile colitispancytopeniaaplastic anemiathrombocytopenic purpuraliver function test abnormaltransaminases increasedrenal impairmentoliguriaproteinuriaazotemiacardio-respiratory arrest.

Like other antibiotics lincomycin can alter the normal bacteria in the colon and encourage overgrowth of some bacteria such as Clostridium difficile which causes inflammation of the colonpseudomembranous colitis

WARNINGBlack BoxRare but sometimes fatal intestinal problems have occurredpseudomembranous colitiswith use of lincomycinThereforeit should only be used to treat serious infections where less toxic antibiotics are not appropriateIt should not be used to treat nonbacterial infections such as upper respiratory infections.

C.diffficile produces toxins A and B which contribute to the development of CDADHypertoxin producing strains of Cdifficile cause increased morbidity and mortalityas these infections can be refractory to antimicrobial therapy and may require colectomyCDAD must be considered in all patients who present with diarrhea following antibacterial useCareful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.

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