Antifungals such as ketoconazole nizoral fluconazole diflucan itraconazole sporanox calcium channel blockers such as verapamil calan, isoptin, verelan diltiazem cardizem, dilacor, tiazac, others clarithromycin biaxin cimetidine tagamet cyclosporine neoral, sandimmune .

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This drug may rarely cause serious liver diseaseGet medical help right away if you develop any signs of liver diseaseincludingsevere stomach/abdominal painpersistent nausea/vomitingyellowing eyes/skindark urineunusual tiredness.

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Risk of serious hepatotoxicitymonitor liver function during therapy and for signs/symptoms of hepatic injurydiscontinue if occursProarrhythmic conditionsMonitor closely for skin rashesdiscontinue if lesions progressRenal or hepatic impairmentElderlyPregnancyCat.CNursing mothers.

AnticoagulantsIn post-marketing experienceas with other azole antifungalsbleeding eventsbruisingepistaxisgastrointestinal bleedinghematuriaand melenahave been reportedin association with increases in prothrombin time in patients receiving fluconazole concurrently with warfarinDuring concomitant treatment with fluconazole and warfarin the prothrombin time was prolonged up to 2-foldprobably due to an inhibition of the warfarin metabolism through CYP2C9In patients receiving coumarin-type or indanedione anticoagulants concurrently with fluconazole the prothrombin time should be carefully monitoredDose adjustment of the anticoagulant may be necessary.

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one dose is ok vaginal candidiasis the recommended dosage of diflucan fluconazole for vaginal candidiasis is 150 mg as a single oral dose.