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Inform patients of the increased risk of bleeding associated with the concomitant use of ZOLOFT and antiplatelet agents or anticoagulantsFor patients taking warfarincarefully monitor the international normalized ratio.
Other important adverse events reported with ZOLOFT overdosesingle or multiple drugsinclude bradycardiabundle branch blockcomaconvulsionsdeliriumhallucinationshypertensionhypotensionmanic reactionpancreatitisQT-interval prolongationTorsade de Pointesserotonin syndromestuporand syncope.
In 354 geriatric subjects treated with ZOLOFT in MDD placebo-controlled trialsthe overall profile of adverse reactions was generally similar to that shown in Table 3[See ADVERSE REACTIONSexcept for tinnitusarthralgia with an incidence of at least 2and at a rate greater than placebo in geriatric patients.
This drug has a black box warningThis is the most serious warning from the Food and Drug AdministrationFDAA black box warning alerts doctors and patients about drug effects that may be dangerousThis drug may increase suicidal thoughts or behavior in some childrenteenagersor young adultsThe risk of this is greatest within the first few months of treatment or when the dosage is changedCall your healthcare provider right away if you have new or sudden changes in your moodbehavioractionsthoughtsor feelingsespecially if they are severePay extra close attention when you start taking this drug or when your dosage is changed.
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