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Mentat is not known to have any side effects if taken as per the prescribed dosage.
Along with the Spacing Guild and the Bene Gesseritthe rise of Leto Atreides II to the title of God Emperor brought with it new problems for the entire Mentat orderLeto’s extremely long lifecoupled with his goal to realize The Golden Path in order to ensure humanity’s survivalsaw him hoard the Spice Melange seemingly without much concern for short-term problems.
Mentats were used extensively by the Great Housesprimarily as political advisors before the rise of God Emperor Leto Atreides II to the throneThanks to their vast memories and ability to organize huge amounts of data they often provided valuable insights that would otherwise be lostLimited Mentat training was also used to augment individuals destined for other political or military roles.
In the aftermath of the Butlerian Jihadcomputers and other forms of thinking technology were made obsolete due to the OCB’s commandment against thinking machinesThou shalt not make a machine in the likeness of a human mindandat the same timethe anti-AI laws had been placed in effectthe punishment of owning such AI device or any kind being immediate deathHuman computersalso known as Mentatstrained as replacements to the mechanical thinking technologyjust as the all-female Bene Gesserit and the Guild of Navigators took up the same functions that had been previously covered by the Thinking Machines prior to the Jihad which banned all thinking technology.
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researchers reported that mini mental state examination scale mmses conducted throughout the study revealed significant improvements with bacopa monnieri supplementation across multiple measures of mental performance, including attention, language and verbal ability, and orientation of time place and person.